WWTR1 and cancer: Furthermore, elevated levels and nuclear localisation of YAP and/or TAZ have been reported in a wide array of human cancers including hepatocellular carcinoma, prostate cancer, colorectal carcinoma (CRC), non-small-cell lung cancer (NSCLC), ovarian cancer, clear cell renal cell carcinoma (ccRCC), pancreatic carcinoma, oesophageal squamous cell carcinoma, urothelial carcinoma of the bladder and skin basal cell carcinoma (Zanconato et al. 2016).