Based on our semiquantitative scoring system, two types of staining were detected in prolactinomas: Type D, characterised by cytoplasmic YAP/TAZ in 20–50% of tumour cells, and Type E, characterised by the absence of staining or weak cytoplasmic in less than 20% of the tumour (Fig. 3A). This evidence concerns the gene WWTR1 and neoplasm.