The suppression of MT1 and MT2A in human hepatocellular carcinoma was related to the dephosphorylation (inactivation) of the transcription factor CCAAT/enhancer-binding protein (C/EBP) α through the PI3K/AKT signaling pathway rather than the gene hypermethylation [25]. The gene discussed is MT1E; the disease is hepatocellular carcinoma.