The association of high MT expression with short-term survival had been demonstrated in small cell lung cancer [121] and non-small cell lung cancer [122], and enhanced expression of MT1F and MT2A isoforms predicted poor clinical outcomes in non-small cell lung cancer in which upregulated MT1F expression was associated with larger primary tumor size and higher grade of malignancy [131]. This evidence concerns the gene MCAT and non-small cell lung carcinoma.