Strikingly, V5-4E-BP1 overexpression (i.e. reduced eIF4E/4E-BP1 ratio) prevented the asTORi-mediated increase of HSV1-dICP0 protein synthesis in transformed cells (4T1 and NT2196), and resulted in greater repression of HSV1-dICP0 infection by asTORi in normal cells (NMuMG). The gene discussed is EIF4E; the disease is infection.