There was a significantly (p = 0.022) higher expression of Cyclin-D1 in tumours of the oral cavity (19.6%) than in those of the larynx (4.7%) and nose (3.2%), but no significant correlation of expression of Cyclin-D1 expression with age, gender, or clinico-pathological features was noted. The gene discussed is CCND1; the disease is neoplasm.