The anti-oxidant action of the combined treatment, as a result of the increase in melanin production, triggered the suppression of key molecules involved in tumor progression (HIF-1α levels in tumor cells and arginase-1 (ARG-1) levels in TAMs) and contributed to a very strong inhibitory effect on the angiogenic capacity of the cell co-culture microenvironment. This evidence concerns the gene HIF1A and neoplasm.