ARID1A and bladder transitional cell carcinoma: Moreover, amounts of EZH2 protein and H3K27me3 were not significantly different, comparing urothelial bladder carcinomas strongly expressing ARID1A protein (median Remmele score: 12) to bladder cancer cases exhibiting ARID1A protein loss or only residual ARID1A expression (median Remmele score: 0) (Fig 4F and 4G).