First, J82 high-grade urothelial bladder cancer cells, neither showing inactivating alterations in subunit genes of the SWI/SNF complex nor genetic alterations in the PRC2/PRC1 complex or Ras pathway genes that might disguise the dependence [22] (S2 Table), were used to generate stable ARID1A-knockdown single-cell clones (Fig 4A and 4C). The gene discussed is ARID1A; the disease is bladder transitional cell carcinoma.