Although we did not reveal a clear co-occurence/mutual exclusivity pattern for ARID1A and TP53/RB1 genetic alterations in bladder carcinoma samples using sequencing data of independent studies [23,24,26,27], depletion of ARID1A in TERT-immortalized normal human urothelial cells (TERT-NHUC) resulted in the induction of p53/p21 expression, potentially in part by MYC deregulation [51]. Here, RB1 is linked to urinary bladder carcinoma.