TYMP and mitochondrial neurogastrointestinal encephalomyopathy: In addition, mutation of the TP gene is associated with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE), an autosomal recessive human disease exhibiting multiple deletions of skeletal muscle mitochondrial DNA (peripheral neuropathy, myopathy, leukoencephalopathy, lactic acidosis, gastrointestinal dysmotility, progressive external ophthalmoplegia, and thin body habitus [18].