GNMT and fatty liver disease: Likewise, GNMT, the most abundant methyltransferase in the liver [55], is associated with fatty liver disease which accompanies hepatic methionine deficiency and homocysteine elevation, resulting mainly from impaired homocysteine demethylation and aberrant reactions of methyltransferase [57–59]; that is, changes in methionine and homocysteine levels could be clinical milestones in progression of co-infected liver malady.