Furthermore, 18 hub genes (TIGD5, C8ORF33, ZNF250, NUDCD1, INTS8, ZNF623, PHF20L1, STIP1, ZNF16, HSP90AB1, LRRC14, DSCC1, POP1, ARHGAP39, PRKDC, YDJC, PUSL1, UBD) showed significantly different expression levels by different tumour stages. Here, INTS8 is linked to neoplasm.