In survival analysis, lower expression of 24 hub genes (BOP1, TIGD5, C8orf76, C8orf33, FAM83H, UBR5, NSMCE2, DCAF13, PYCRL, NUDCD1, INTS8, ZNF623, TOP1MT, STIP1, HSP90AB1, PRR7, COMMD5, DSCC1, POP1, ARHGAP39, PRKDC, YDJC, PUSL1, STAU2) was associated with significantly longer OS of HCC patients. This evidence concerns the gene ZNF623 and hepatocellular carcinoma.