In survival analysis, lower expression of 24 hub genes (BOP1, TIGD5, C8orf76, C8orf33, FAM83H, UBR5, NSMCE2, DCAF13, PYCRL, NUDCD1, INTS8, ZNF623, TOP1MT, STIP1, HSP90AB1, PRR7, COMMD5, DSCC1, POP1, ARHGAP39, PRKDC, YDJC, PUSL1, STAU2) was associated with significantly longer OS of HCC patients. This evidence concerns the gene HSP90AB1 and hepatocellular carcinoma.