Furthermore, 18 hub genes (TIGD5, C8ORF33, ZNF250, NUDCD1, INTS8, ZNF623, PHF20L1, STIP1, ZNF16, HSP90AB1, LRRC14, DSCC1, POP1, ARHGAP39, PRKDC, YDJC, PUSL1, UBD) showed significantly different expression levels by different tumour stages. The gene discussed is POP1; the disease is neoplasm.