In survival analysis, lower expression of 24 hub genes (BOP1, TIGD5, C8orf76, C8orf33, FAM83H, UBR5, NSMCE2, DCAF13, PYCRL, NUDCD1, INTS8, ZNF623, TOP1MT, STIP1, HSP90AB1, PRR7, COMMD5, DSCC1, POP1, ARHGAP39, PRKDC, YDJC, PUSL1, STAU2) was associated with significantly longer OS of HCC patients. The gene discussed is DSCC1; the disease is hepatocellular carcinoma.