Furthermore, 18 hub genes (TIGD5, C8ORF33, ZNF250, NUDCD1, INTS8, ZNF623, PHF20L1, STIP1, ZNF16, HSP90AB1, LRRC14, DSCC1, POP1, ARHGAP39, PRKDC, YDJC, PUSL1, UBD) showed significantly different expression levels by different tumour stages. This evidence concerns the gene PUSL1 and neoplasm.