Furthermore, 18 hub genes (TIGD5, C8ORF33, ZNF250, NUDCD1, INTS8, ZNF623, PHF20L1, STIP1, ZNF16, HSP90AB1, LRRC14, DSCC1, POP1, ARHGAP39, PRKDC, YDJC, PUSL1, UBD) showed significantly different expression levels by different tumour stages. Here, ZNF16 is linked to neoplasm.