To achieve a weaker genetic manipulation of ITP, we used the Impl2-GAL4 driver, which targets only a subpopulation of the ITP-producing neurons: the neurosecretory neurons in the brain (ipc-1 cells and the ipc-2a cells) and the LBD neurons in the periphery (Figs 2A, 2B and S5). This evidence concerns the gene LGALS4 and autoimmune thrombocytopenic purpura.