Previous studies have shown that knock down of ASCT2 results in tumor growth attenuation in vitro (Nicklin et al., 2009; Wang et al., 2014, 2015; van Geldermalsen et al., 2016; Schulte et al., 2018) and in vivo (Wang et al., 2015; van Geldermalsen et al., 2016), and the viability of ASCT2 knockout mice suggests that pharmacological targeting of ASCT2 may not affect normal cells (Nakaya et al., 2014; Masle-Farquhar et al., 2017). Here, SLC1A5 is linked to neoplasm.