NETs have been shown to sequester circulating tumour cells at distant sites and promote metastasis.33 Extravasation into tissues is aided by interactions between β2 integrin on neutrophils and ICAM-1 on tumour cells, promoting anchoring to the vascular endothelium.34 Tumour-derived G-CSF can initiate a pre-metastatic environment in distant organs, mobilizing neutrophils from the bone marrow to swarm at the metastatic site before tumour cells arrive.35 This evidence concerns the gene ICAM1 and neoplasm.