For example, in terms of neutrophil recruitment, there is an interest in targeting the CXCR2 pathway.51 Relating to neutrophil polarization, there have been trials of TGF-β inhibitors as a cancer therapy.52 With regard to direct neutrophil–tumour interaction, there has been interest in the use of NE inhibitors.53 This evidence concerns the gene TGFB1 and neoplasm.