IFNB1 and neoplasm: Of key importance, TGF-β blockade promoted a T cell antitumour response.10 Using IFN-β1−/− tumour-bearing mice, the Jablonska group have shown interferon beta (IFN-β) to have the opposite effect to TGF-β on TAN polarization, i.e. IFN-β promotes antitumour N1 TAN.11