Inclusion:Moderate to severe Crohn’s disease- CDAI 250450- Fasting CRP > 7.5 mg/LExclusion:- Fluctuating dosages of immunosuppression 4 weeksa- > 20 mg prednisolone (or equivalent) 4 w previouslya- Anti-TNFα or anti-α4 integrin treatment 12 w previouslya. This evidence concerns the gene TNF and Crohn disease.