Inclusion:- Moderate to severe Crohn’s disease (CDAI 220400)- Disease located to the terminal ileum of right colon- Steroid-dependent / refractory diseaseExclusion:- Disease affecting the upper GI tract, proximal small intestine, transverse colon, or left colon.- Stricturing disease- Penetrating disease- Extraintestinal disease- Anti-TNFα therapy in preceding 90 da. The gene discussed is TNF; the disease is Crohn disease.