TNF and Crohn disease: Inclusion:Moderate to severe Crohn’s disease- CDAI 220450- Active inflammationb- Inadequate response to immunosuppression Exclusion:- Fluctuating dosages of immunosuppressiona- > 20 mg prednisolone (or equivalent)- No concurrent dependence on anti-TNFα therapy during trial- EC, abdominal or pelvic fistulas with abscess