CXCR3 and colitis: Frequencies of CXCR3+ cells increase in mesenteric lymph nodes and Peyer’s patches associated with Th1-mediated injury, and inhibition of CXCL10 attenuates the rate and intensity of colitis and intestinal inflammation.63,64 CXCR3-deficient mice also develop a much milder colitis in response to dextran sulphate sodium.