Amongst the most significant NFT-associated transcripts are those implicated in tau pathophysiology, including CDK5R1, which encodes the regulatory p35 subunit of cyclin-dependent kinase 5, the truncated form (p25) of which hyperphosphorylates tau and is implicated in neuronal death in neurodegenerative diseases [15, 40]. This evidence concerns the gene CDK5R1 and neurodegenerative disease.