The delayed excretion kinetics of 177Lu-11 compared to 177Lu-10 and 177Lu-PSMA I&T, caused by 97% plasma protein binding of 177Lu-11, led to a significantly improved tumor uptake at 24 h p.i. However, in the context of the new generation of high plasma protein binding PSMA inhibitors with improved tumor uptake, first-in-man studies have to prove if an increased diagnostic, therapeutic, or theranostic value exists and if high plasma protein binding is the next big step in PSMA drug development. Here, FOLH1 is linked to neoplasm.