Thus, since the occurrence of ROS dysfunctions following rotenone exposure is well described (Dukes et al., 2005, Sherer et al., 2003) and evidences suggest that accumulation of insoluble and phosphorylated Tau in neurodegenerative diseases is a toxic event compromising neuronal function through the induction of ROS and impairment of protein clearance machinery (Ciechanover and Brundin, 2003). Here, MAPT is linked to neurodegenerative disease.