By contrast, we showed that through the binding and ligation of immobilized CG4 mAb, GPR56 receptor cross-linking in melanoma cells promoted the shedding of GPR56-NTF and subsequent activation and signaling of GPR56-CTF via the Gα12/13 and RhoA pathways, resulting in IL-6 production. Here, ADGRG1 is linked to melanoma.