TET2 and myeloid neoplasm: TET2 is a dioxygenase enzyme using alpha-ketoglutarate (αKG), Fe2+, and O2 for hydroxylation of DNA methylcytosine (5mC), converting it into 5-hydroxymethylcytosine (5hmC), which can be converted into other derivatives, including ultimately demethylated DNA.TET2 is one of the most commonly mutated genes in myeloid malignancies, andTET2 mutations are also found in apparently hematologically normal individuals with clonal hematopoiesis13,14.