BCL2 and acute myeloid leukemia: Some of the most promising novel therapies in AML include small-molecule inhibitors of epigenetic enzymes, inhibitors of anti-apoptotic proteins such as the B-cell leukemia/lymphoma-2 (BCL2) family, and immunotherapy, such as PD-1 axis inhibitors, bispecific antibodies to CD3 and CD123 (expressed in the majority of AML cells), and CAR-T cell approaches.