According to Boonnak and colleagues, CD8+ T cells can be particularly affected by the Fas-ligand mediated pathway, where Fas-ligand was upregulated on plasmocytoid dendritic cells during lethal H5N1 infection in mice, which then lead to apoptosis of influenza-specific CD8+ T cells in the lung draining lymph nodes (86). The gene discussed is CD8A; the disease is influenza.