CD8A and neoplasm: In a study analyzing the molecular signature of tumor-infiltrating lymphocytes (TILs) of non-small cell lung carcinoma, it was found that the CD8+ TILs that infiltrated tumors at a high density had high levels of PD-1 and the costimulatory molecule 4-1BB (48), molecules that are upregulated upon TCR engagement and have been associated with both exhaustion and activation (4, 49, 50).