Predominantly placenta-expressed genes, down-regulated in module M1, are regulators of fetal growth (CSH1, HSD11B2) (157, 158), metabolism (ESRRG) (159), estrogen synthesis (HSD17B1) (160), and immune functions (LGALS14) (153), some of which were reported to be down-regulated in preeclampsia (30, 91, 130, 155, 161, 162). This evidence concerns the gene HSD11B2 and preeclampsia.