Since BCL6 overexpression up-regulated ARNT2 both in ischemia and hypoxia but not vice versa, we propose that BCL6 is upstream of ARNT2. The up-regulation of these two transcription regulatory genes sensitize the trophoblast to ischemia, leading to the early dysregulation of modules M1 and M2, thus promoting preterm preeclampsia (Figure S7 in Supplementary Material). This evidence concerns the gene ARNT2 and preeclampsia.