NFE2L2 and major depressive disorder: Previously, we reported that pretreatment with SFN has prophylactic effects on depression-like phenotype and dendritic spine changes in an inflammation-induced model of depression (Zhang et al., 2017), and that novel Nrf2 activators (TBE-31 and MCE-1) demonstrate antidepressant effects in an inflammation model of depression (Yao et al., 2016b).