These include Parkinson's and Alzheimer's disease, amyotrophic lateral sclerosis (ALS) and Parkinsonian disorders e.g., progressive supranuclear palsy, all of which have been linked to polymorphisms in the microtubule stabilizing protein TAU (MAPT) (Zhang et al., 2017). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.