In the aspect of malignant hematopoiesis, an abnormally elevated JMJD3 level in association with an overactivated NF-κb/innate immunity pathway was documented in human CD34+ hematopoietic stem/progenitor cells of the myelodysplastic syndrome (MDS)15, a preleukemic state that may evolve into acute myeloid leukemia (AML) or acute lymphoid leukemia (ALL). The gene discussed is KDM6B; the disease is acute lymphoblastic leukemia.