In this regard, in parallel to the observation that JMJD3 expression is highly inducible by ATRA51, C/EBPβ has been shown to mediate ATRA-induced differentiation of AML cells39,52, and to suppress the malignancy of chronic myeloid leukemia blasts by inducing their myeloid maturation53,54. The gene discussed is KDM6B; the disease is acute myeloid leukemia.