In accordance with its role in mouse AML models, the lentiviral vector-delivered JMJD3 expression-cassette resulted in JMJD3 overexpression and decreased the colony-forming potential of the primary leukemic blasts in six out of seven cases (in one M2b, one M3, two M4, and one unclassified AML case but only in one out of two M5 cases) (Fig. 3a and Supplementary Fig. 2a). This evidence concerns the gene KDM6B and acute myeloid leukemia.