As evidenced by western blotting assay and flow cytometric analyses of myeloid differentiation antigen CD11b expression, cell survival, and cell cycle (Fig. 3e, h and Supplementary Fig. 3c, e), the forced expression of WT JMJD3 but not H1390 mutant or empty vector potently drove the myeloid differentiation of AML cells in a demethylase-dependent manner (by 50-fold), to be accompanied by the moderately reduced survival (by seven-fold) and proliferation of leukemia cell. Here, ITGAM is linked to leukemia.