Similar to what we observed in the expressional regulation of JMJD3 in AML cells, C/EBPβ mRNA level was decreased in primary AML blasts compared to normal counterparts (Supplementary Fig.6f), and ChIP-seq analysis of AML cells and transfection experiment of normal c-Kit+ BM progenitors indicated that the transcription of C/EBPβ was likely repressed by oncogenic proteins such as PML-RARα (Supplementary Fig. 6g, h). Here, RARA is linked to acute myeloid leukemia.