RUNX1T1 and acute myeloid leukemia: Particularly, the reduction in JMJD3 mRNA level was most prominent in AML subtypes including M1, M2 (M2 without AML-ETO (AE) fusion protein), M2b (M2 with AE fusion protein), and M3 that show immature features of granulocytic progenitors (Fig. 1c).