In this regard, in parallel to the observation that JMJD3 expression is highly inducible by ATRA51, C/EBPβ has been shown to mediate ATRA-induced differentiation of AML cells39,52, and to suppress the malignancy of chronic myeloid leukemia blasts by inducing their myeloid maturation53,54. Here, KDM6B is linked to chronic myelogenous leukemia, BCR-ABL1 positive.