Likewise, JMJD3 overexpression showed myeloid differentiation-induction and apoptosis-induction effect in one M2 (without AE), three M3/APL, two M4, and one or two out of three M5 human primary blastic BM samples (Fig. 3b, c and Supplementary Fig. 2b, d). Here, KDM6B is linked to acute promyelocytic leukemia.