In agreement, JMJD3 overexpression upregulated the C/EBPβ mRNA level in human AML cells cultivated in vitro or HL-60 cells repopulated in the NOD/SCID mice as well as in three subtypes of mouse AML cells, and also the RIPK3 mRNA level in these cells except NB4 cells, the mouse M3/APL cells and the mouse M5 cells expressing MF9 (Fig. 4j, l and Supplementary Fig. 4s). This evidence concerns the gene CEBPB and acute myeloid leukemia.