In another aspect, other genomic indicators of poor immunogenicity, such as epigenetic downregulation of chemokines (lower T-cell recruitment), upregulation of endothelin receptors (higher tumor angiogenesis and survival), MHC downregulation and low neoantigen load (lower antigen exposure), and impaired DC function (lower antigen presentation), have been described and attributed to what is popularly termed “cold” tumor types78,79. The gene discussed is HLA-C; the disease is neoplasm.