The profile of this latter process was most similar to the canonical AID (c-AID) mutational signature recently described in a chronic lymphocytic leukemia WGS study (Fig. 5c)29, and it was likely missed by previous NNMF studies because it is very localized in the genome and present in few types of cancers only. This evidence concerns the gene SGO1 and B-cell chronic lymphocytic leukemia.