Though glycans have primarily been shown to alter the expression of cell-surface receptors to modulate cellular responses17,22,42, we did not observe consistent statistically significant differences in cell-surface expression of IGF1R or various integrin α and β receptors in GCNT2 KD, GCNT2 OE, or control melanoma cells (Supplementary Fig. 6a–p). Here, IGF1R is linked to melanoma.