FN1 and melanoma: Because melanoma cells express numerous integrin α and β chains and integrin-ECM interactions are known to regulate cancer cell survival19, we plated GCNT2 KD, GCNT2 OE, and control cell variants on a mixture of fibronectin, laminin and collagen, common components of the tumor microenvironment and well-described integrin ligands39 (Fig. 5g).