Of these, the downregulation of β1,6-N-acetylglucosaminyltransferase, GCNT2, in melanoma cells was of particular interest, as this is the enzyme that catalyzes the transfer of N-acetylglucosamine to galactose residues on polyLacNAcs to form I-branched glycans (Fig. 2e). This evidence concerns the gene GCNT2 and melanoma.