Currently, we do not know whether individual binding of ZCCHC3 or cGAS to dsDNA promotes the interaction of the two proteins, and subsequently increases the affinity of the complex to dsDNA, or alternatively, viral infection firstly induces formation of ZCCHC3 and cGAS complex through unknown mechanisms, which has much higher affinity to dsDNA than each of them alone. Here, CGAS is linked to viral infectious disease.