As retinoid treatments were found to be synergistic with flavonoids, including EGCG [16,17], we investigated the cytotoxic effects of the EGCG plus IIF combination and the molecular network underlying the cytotoxic effects in a neuroblastoma cell line BE(2)-C, a clone of the SK-N-BE(2) neuroblastoma cell line having N-MYC amplification and p53 mutation and isolated from a bone marrow biopsy that was taken in a neuroblastoma patient after repeated courses of chemotherapy and radiotherapy. The gene discussed is TP53; the disease is neuroblastoma.