The activation of SYK by LMP2A made premalignant cells and tumor cells very sensitive to the effects of TAK-659, as 60 nM TAK-659 completely inhibited SYK phosphorylation in the LMP2A-positive cells while inducing SYK phosphorylation in the LMP2A-negative MYC lymphoma cells. This evidence concerns the gene SYK and neoplasm.