RBPJ and infection: As expected, the EBNA3C knockout (3C KO) and EBNA3C RBPJ BM (3C RBPJ BM) viruses failed to regulate the COBLL1 mRNA level, whereas EBNA3C-competent viruses (WT and 3C Rev) resulted in a rapid reduction of COBLL1 gene expression over a period of 30 days after infection (Fig. 3A).