DGKB and epilepsy: It is also interesting to note that previous studies have shown a reduction in dendritic spines in epilepsy patients (Muller et al., 1993; Scheibel et al., 1974), that DGKβ controls dendritic spine outgrowth and maturation (Hozumi et al., 2009), and that VPA treatment increases dendritic spine formation in mouse models (Yang et al., 2016).