PRRT2 and bipolar disorder: Numerous studies have identified upregulated PKC activity in bipolar disorder patients (Friedman et al., 1993; Wang and Friedman, 1996), with this activity being reduced by both lithium (Friedman et al., 1993; Wang and Friedman, 1989) and VPA (Ramadan et al., 2011; Watson et al., 1998) in animal models and patient studies (Katsel et al., 2008; Soares and Mallinger, 1997; Wang et al., 2001).