DGKH and bipolar disorder: Associations with bipolar disorder have been made with DGKβ and DGKη (Baum et al., 2007; Kakefuda et al., 2010; Moya et al., 2010; Squassina et al., 2009), with lithium treatment resulting in accumulation of DAG in a range of models (Brami et al., 1993; Drummond and Raeburn, 1984), independent of phospholipase D (Nilssen et al., 2005).