IL6 and ductal breast carcinoma in situ: In H&E analysis of whole tumor tissue slides a more invasive phenotype and large necrotic areas was observed in hPreAd co-injected tumors relative to the other tumors at 8–10 weeks post-injection, and the treatment with IL-6 NAb inhibited tumor growth and progression of DCIS.com in subcutaneous xenografts (Fig. 5e), indicating that hPreAd promotes tumor growth and progression of DCIS.com via IL-6-mediated signaling.