The volume of tumors treated with IL-6 NAb was decreased in the mice co-injected with DCIS.com and hPreAd (207.8 ± 111.5 mm3, P = 0.012) or in the mice injected with DCIS.com alone (338.1 ± 89.4, P = 0.154) relative to the untreated mice. Here, IL6 is linked to ductal breast carcinoma in situ.