S100A4 and ductal breast carcinoma in situ: Similarly, our study demonstrated that DCIS.com cells suppressed the differentiation of preadipocyte into mature adipocyte, and made preadipocytes have more elongated fibroblast morphology accompanying with the upregulation of FSP1 and α-SMC, resulting in the acquisition of aggressive phenotype with a high proliferative and migratory activity.