The spheroids were usually larger in DCIS.com cultures treated with 50 ng/ml IL-6 or with hPreAd conditioned media than in the untreated control, but administration of 3 μg/ml IL-6 NAb or IL-6R NAb caused the decrease in the spheroid diameter which had been increased by hPreAd conditioned media (Fig. 4e). The gene discussed is IL6R; the disease is ductal breast carcinoma in situ.