Moreover, IL-6 treatment caused a significant increase in DCIS.com cell proliferation and migration, but no additional migration effect of IL-6 on SUM225 was observed, indicating that the sensitivity to IL-6 is absent in SUM225 or the different factors involved in the reciprocal cross talk between preadipocytes and SUM225 may not exert significant effects on migration of SUM225 cells. This evidence concerns the gene IL6 and ductal breast carcinoma in situ.