Acting as a sponge cushion linking SET1A and pRB1, CUDR increases the expression of HULC, β-catenin, TERT, and c-Myc in human liver cancer stem cells, thus initiating stem cell malignant transformation [52–54] in a metabolic paradigm; however, CUDR can form a complex with p53 to promote hepatocarcinogenesis by transcriptionally activating PKM2 [55]. The gene discussed is UCA1; the disease is liver cancer.