TP53 and neoplasm: Conspicuously, lncRNAs can interact with multiple molecules and/or signaling pathways (e.g., HULC with C-Myc and p53); they participate in diverse physiological and pathological processes by acting as transcriptional, post-transcriptional, or epigenetic regulators (e.g., UCA1 with HK2, C-Myc, miR-143 and miR-16); and they can target multiple metabolic processes (e.g., UCA1 in glycolysis and glutaminolysis) in a tumor simultaneously, which undoubtedly will illuminate the development and selection of therapeutic targets to prevent tumorigenesis and progression.