Moreover, overexpressing activated Akt in A549 cells induced upregulation of Snail and Slug and reversed API-mediated inhibition of the invasive ability, suggesting that Akt inhibition by API is a general phenomenon in NSCLC cells and may be the main cause for the API-mediated suppression of Snail family-induced cell motility. The gene discussed is SNAI1; the disease is non-small cell lung carcinoma.