Moreover, our results showed that API-mediated downregulation of MMP-2 and MMP-9 was only observed in A549 cells, but not in other NSCLC cell lines (CL1–5 and H1975), suggesting that inhibition of MMP-2 and MMP-9 by API might be cell-type specific. This evidence concerns the gene MMP9 and non-small cell lung carcinoma.