The present data demonstrated that API treatment of NSCLC cells which harbor the WT or mutant EGFR can suppress CD26 expression and the interplay of downstream targets, p-Akt and Snail/Slug, resulting in inhibition of the EMT-mediated invasive ability; the mechanism is schematically illustrated in Fig. 6e. The gene discussed is SNAI2; the disease is non-small cell lung carcinoma.