In other words, LCH is an inflammatory process that is protracted by gene mutations, which we promote as an IL-1 loop model that was quoted in the WHO Classification of Tumours of Haematopoietic and Lymphoid tissues Revised 4th Edition in 2017 [2] as the major pathway in the development of Tumours derived from Langerhans cell. This evidence concerns the gene IL1B and neoplasm.