The mRNAs expression of CD44, HER2, CDH1, OAS1, OAS2, OAS3, OASL, ISG15, STAT1, CCND1, and WNT5A were significantly upregulated in tumor while only KIT was significantly downregulated in tumor (TCGA) compared to normal (TCGA normal + GTEx normal) (Fig. 8a). The gene discussed is ISG15; the disease is neoplasm.