In the LEADER and SUSTAIN 6 trials, the glucagon-like peptide-1 receptor agonists (GLP-1 RAs) liraglutide and once-weekly semaglutide, significantly decreased the risk for major CV adverse events among T2DM patients with established CVD or more than one CV risk factor [3, 4]. Here, GLP1R is linked to type 2 diabetes mellitus.