In the EMPA-REG OUTCOME [1] and the CANVAS Program [2], the sodium–glucose co-transporter 2 (SGLT2) inhibitors empagliflozin and canagliflozin reduced the major cardiovascular (CV) adverse events among patients with diabetes mellitus type 2 (T2DM) and established CVD or at high risk for CV events. Here, SLC5A2 is linked to type 2 diabetes mellitus.