In the LIMMA analysis of any virus-infected (Virus(+)) (n = 8) versus uninfected primary adenocarcinoma specimens (Virus(−)) (n = 2), ACTC1 and PCSK2 were found to be significantly down-regulated in Virus(+) (Table 2; Additional file 7: Figure S6). The gene discussed is PCSK2; the disease is adenocarcinoma.