Dual-specificity tyrosine-phosphorylation-regulated kinase (DYRK), can prevent metabolic disorders like obesity by reducing fat mass [68]; while a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS), was widely reported to be associated with adipogenesis, fat content, and obesity [69–72]. The gene discussed is DYRK1A; the disease is metabolic disease.