CXCL1 and infection: The chemokine components of the granulocyte adhesion and diapedesis pathway showed some of the greatest differences in phase-dependent infection induction (Fig. 6), including the primary neutrophil chemokine Cxcl1 and the strong mucosal lymphocyte chemokine Ccl28 [53, 54], which had differential fold change (DFC; i.e., ratio of fold change during diestrus-phase infection to fold change during estrus-phase infection) values of 3.8 and 3.9, respectively.