These include the previously discussed chemokines Cxcl1, Cxcl10, and Ccl5; the formyl peptide-specific chemoattractant receptor Fpr2, which has an identified role in host response to some bacterial infections [45]; the endogenous antimicrobials beta-defensin 1 (Defb1) and reactive-oxygen-species (ROS)-producing enzyme NADPH Oxidase (NOX2; Cybb); and major regulators of general immune activation including a component of the classic pro-inflammatory transcription factor, Nuclear Factor kappa-B (Nfkb2). This evidence concerns the gene DEFB1 and bacterial infectious disease.