Taking into account the tight correlations (r = 0.97) between jugular and peripheral plasma levels of NCAM1 and among repeated evaluations over time (r = 0.98) performed in the 2nd MS population, which indicate the presence of particularly conserved individual plasma patterns in two MS disease cohorts, our findings suggest that NCAM1 plasma levels could be related to MS disease, independently from the CCSVI status. The gene discussed is NCAM1; the disease is myeloid sarcoma.