Altogether the transcriptome analysis in jugular wall and the transcriptome analysis in PBMC from MS patients (Comabella et al. 2016; Srinivasan et al. 2017; Iglesias et al. 2004) suggest dysregulation of histone, cytoskeleton and CD86 genes as a general signature of altered gene expression in different cells and tissues of MS patients. This evidence concerns the gene CD86 and myeloid sarcoma.