Simultaneous occurrence of EGFR and phosphatase and tensin homolog (PTEN) alterations as well as an interplay between these two factors can be observed in various cancers such as cancers of the brain, lung and prostate (Bratland et al. 2009; Chott et al. 1999; Wozniak et al. 2017). This evidence concerns the gene EGFR and brain cancer.