AKT1 and cancer: Alternatively, as shown in the reported studies, MMP9 enhance EGFR expression via PI3K/AKT pathways in cancers of the lung, ovaries, breast and brain (Chen et al. 2016; Comamala et al. 2011; Elbaz et al. 2015; Garrido et al. 2017; Pei et al. 2014).