In addition, miR-21-5p was controlled by one gene called miR-21 and in previous studies, miR-21 has been proved to be capable of targeting many tumor suppressors such as PTEN (Meng et al., 2007), RECK (Gabriely et al., 2008), BTG2 (Liu et al., 2009) and TP63 (Papagiannakopoulos et al., 2008). Here, PTEN is linked to neoplasm.