TRPM3 and myalgic encephalomeyelitis/chronic fatigue syndrome: In contrast, ionic currents in the presence of PregS were mostly resistant to ononetin in isolated NK cells from CFS/ME patients (Fig. 3c, d), in comparison with HC (Fig. 3e, f, g (p = 0.0005)), showing significant loss of the TRPM3 channel activity in CFS/ME patients.