These polyphenols inhibit the expression and activity of EGFR1 and EGFR2 (s. HER2) (Azios & Dharmawardhane 2005; Fridrich et al. 2008), and elevated EGFR tumor expression is generally associated with higher cancer progression and metastasis (Buret et al. 1999). This evidence concerns the gene EGFR and neoplasm.