ESR2 and neoplasm: Contrary to the previous results, resveratrol was found to promote tumor growth and metastases incidence in immunocompromised mice grafted with low-metastatic ERα-negative/ERβ-positive MDA-MB-231 or highly-metastatic ERα/ERβ-negative MDA-MB-468 breast cancer cells (Castillo-Pichardo et al. 2013).