NFKB1 and breast cancer: In vitro studies using human MDA-MB-231 and MCF-7 breast cancer cells showed downregulation of MMP-2 and -9, EGFR and upregulation of TIMP-1 and -2, involvement of FAK/ERK/NF-κB signaling pathways with concomitant inhibition of cellular invasion (Farabegoli et al. 2011; Sen et al. 2010).