Genistein (Akiyama et al. 1987; Peterson & Barnes 1991; Pagliacci et al. 1994), luteolin (Huang et al. 1999; Lee et al. 2002), quercetin (Agullo et al. 1997), and butein (Yang et al. 1998) affect tumor development by suppressing the activity of epidermal growth factor receptor (EGFR) tyrosine kinase resulting in downstream effects on number of substrates such as serine/threonine kinases, mitogen-activated protein kinases (MAPKs), and rapidly accelerated fibrosarcoma kinases (RAFs) (Carpenter & Cohen 1990). Here, EGFR is linked to neoplasm.