Hypoxia of the white adipose tissue may be induced by obesity and can further lead to endocrine alterations promoting the secretion of proinflammatory and angiogenic cytokines, and downregulating CCAAT-enhancer binding protein-alpha (C/EBPα) thus inhibiting apoptosis and stimulating cell proliferation (Ye et al. 2007; Khan et al. 2013). Here, CEBPA is linked to obesity due to melanocortin 4 receptor deficiency.