EGFR and cyst: Thus, these authors suggested that Pkd1 mutation-induced upregulation of HDAC6 might slow the trafficking of EGFR from early endosomes to late endosomes along microtubules for degradation through deacetylation of α-tubulin, leading to phosphorylation of ERK1/2 to facilitate cyst formation (Liu et al. 2012b).