Main components of the microenvironment are monocyte-derived nurselike cells (NLCs), and other myeloid cells, mesenchymal-stromal cells, T cells and NK cells, all of which communicate with CLL cells through a complex and intertwined network of adhesion molecules, chemokine receptors, tumor necrosis factor (TNF) family members, and soluble factors (reviewed in (Ten Hacken & Burger, 2016). This evidence concerns the gene TNF and B-cell chronic lymphocytic leukemia.