Beside del17p/TP53 mutation which is the strongest CLL biomarker for response to therapy, other mutations (e.g., SF3B1, ATM, NOTCH1, BRIC3) have been reported to correlate with the outcome of the disease, but they are not actionable yet (Lazarian et al., 2017). This evidence concerns the gene NOTCH1 and B-cell chronic lymphocytic leukemia.