Other circumstantial evidence might help us understand disturbances of hepcidin levels in AILD; IL-22 has been shown to induce hepcidin expression during its control of early immune response (Armitage et al. 2011), while disruption of this cytokine in T-cell mediated hepatitis causes progressive damage in the liver (Pan et al. 2014). This evidence concerns the gene HAMP and hepatitis A virus infection.