In mouse models of NAFLD with hepcidin knockout there is an interesting picture of liver damage; although loss of hepcidin is associated with ameliorated liver steatosis, liver fibrosis is present early and is more pronounced compared to mice with normal hepcidin expression (Lu et al. 2016) There are studies that suggest that hepcidin levels are insufficiently increased in relation to ferritin depos in NAFLD (Mitsuyoshi et al. 2009; Barisani et al. 2008). This evidence concerns the gene HAMP and Hepatic fibrosis.