Indeed, reduced hepcidin/ferritin ratio has been detected in NASH and in dysmetabolic iron-overload syndrome or DIOS (frequently present in patients with NAFLD), but not in NAFLD patients with simple steatosis (Mitsuyoshi et al. 2009; Barisani et al. 2008). This evidence concerns the gene HAMP and metabolic dysfunction-associated steatohepatitis.