IL6 and neoplasm: The fact that the blockade of IL-6 or of the IL-6R lead to PEc downregulation together with the evidence obtained by IHC which indicates that the expression of both of these factors: a) is co-localized in the tumor, b) is proportional and c) it increases as the tumors progress, may be indicative that the oncogenic effect of IL-6 such as the involvement in EMT may be generated through IGF-1Ec isoform and PEc secretion.