Prostate cancer cell lines under the influence of the IR (innate or adaptive) presented a significant increase of IGF-1Ec upregulation (similar to the one observed after IL-6 treatment) (p < 0.001, students t test, n = 3) which was abolished when these cells were treated with anti-IL-6R antibody (Fig. 3d). The gene discussed is IL6; the disease is Familial prostate cancer.