The activation of the IIR generated by the prostate cancer establishment in vivo was examined by assessing the expression of mouse MIG-1, an angiostatic cytokine induced by IFNγ, that can be secreted by the natural killer cells of SCID mice and plays physiologically important roles in promoting innate and adaptive IR (Haabeth et al., 2011). Here, VPS4B is linked to prostate cancer.